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Thomas Comery Selected Research

begacestat

11/2009Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
12/2008Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.

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Thomas Comery Research Topics

Disease

2Alzheimer Disease (Alzheimer's Disease)
11/2009 - 12/2008
1Amyloid Plaque
11/2009
1Cerebral Amyloid Angiopathy (Congophilic Angiopathy)
11/2009
1Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
01/2008

Drug/Important Bio-Agent (IBA)

2begacestatIBA
11/2009 - 12/2008
2Amyloid Precursor Protein Secretases (beta-Secretase)IBA
11/2009 - 12/2008
1Amyloid (Amyloid Fibrils)IBA
11/2009
1Proteins (Proteins, Gene)FDA Link
11/2009
1SulfonamidesIBA
11/2009
1ThiophenesIBA
11/2009
1Amyloid beta-PeptidesIBA
11/2009
1Peptides (Polypeptides)IBA
11/2009
1Pharmaceutical PreparationsIBA
01/2008
1Methylphenidate (Ritalin)FDA LinkGeneric
01/2008
1Atomoxetine Hydrochloride (Strattera)FDA LinkGeneric
01/2008

Therapy/Procedure

1Drug Therapy (Chemotherapy)
01/2008